Title

Rare Earth Aluminosilicate Glasses for in Vivo Radiation Delivery

Abstract

This chapter discusses rare earth aluminosilicate (REAS) glasses for use as in vivo radiation delivery vehicles. The glasses discussed herein contain >5 mol% Y2O3, Sm2O3, Ho2O3, or Dy2O3 as a primary component of the glass and are used in the form of microspheres (20 to 40 μm in diameter) or seeds (cylinders ≈0.8 mm in diameter x 5 mm long) to deliver large doses (>15,000 rads (cGy)) of beta radiation to sites inside the body. Relevant nuclear and physical properties of the rare earth aluminosilicate glasses are reviewed with emphasis on dose delivery and the chemical durability of REAS glasses in in vitro environments. Results of clinical trials where a yttrium aluminosilicate glass is used to irradiate malignant tumors in the liver of humans are described.

Department(s)

Materials Science and Engineering

Keywords and Phrases

Composition effects; Dosimetry; Durability; Nuclear properties; Physical properties; Rare earth elements; Silicates; Yttrium compounds; Aluminosilicate glasses; Chemical durability; In vivo radiation delivery; Liver; Malignant tumors; Microspheres

International Standard Serial Number (ISSN)

2521059

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1994 Trans Tech Publications, All rights reserved.

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