Preparation of Hollow Hydroxyapatite Microspheres

Abstract

The preparation of hollow hydroxyapatite (HA) microspheres as potential drug-delivery vehicles was investigated. A lithium-calcium-borate (10Li2O-15CaO-75B2O3) (mol%) glass, made by fusing the components at 1100°C for 1 h, was ground to a powder and passed through a flame at ∼1400°C to spheroidize the particles. The resulting glass microspheres (106-125 μm in diameter) were reacted in 0.25 M K2HPO4 solution for 5 days at 37°C and pH 10-12, resulting in the formation of porous, hollow microspheres of a calcium phosphate (Ca-P) material with external diameters similar to those of the original glass particles. Heat treatment at 600°C for 4 h partially converted the Ca-P material to HA, as confirmed by X-ray diffraction, and also increased the strength of the hollow microspheres.

Department(s)

Materials Science and Engineering

Keywords and Phrases

Hollow Hydroxyapatite; Microspheres

International Standard Serial Number (ISSN)

0957-4530

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2006 Springer Netherlands, All rights reserved.

Publication Date

01 Jul 2006

Link to Full Text

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