Title

Manipulation of Porous Bioceramic Microstructures by Freezing of Suspensions Containing Binary Mixtures of Solvents

Abstract

In our previous work, using a unidirectional freeze-casting method, it was observed that the addition of certain polar organic solvents, such as 1,4-dioxane and glycerol, to aqueous suspensions of hydroxyapatite (HA) resulted in drastic changes to the microstructure. The objective of the present work is to provide a rationalization of the observed microstructures. Phase separation of the binary water-dioxane and water-glycerol mixtures during freezing, and the physical chemistry of the solvent mixtures, such as the ability of the polar organic solvents to modify the hydrogen bonding of water, are the key factors influencing the freeze-cast microstructures. The porous HA constructs could be applied as scaffolds for bone repair.

Department(s)

Materials Science and Engineering

Keywords and Phrases

Bone Repair; Freeze-Casting Method

Library of Congress Subject Headings

Hydroxyapatite

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2008 John Wiley & Sons, All rights reserved.

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