In Vitro Bioactive Characteristics of Borate-based Glasses with Controllable Degradation Behavior
Silicate-based bioactive glasses undergo incomplete conversion to a calcium phosphate material after in vivo implantation, which severely limits their biomedical application. In this communication, novel borate-based glasses with controllable degradation behavior were developed and their bioactive potential was investigated in vitro. when immersed in a 0.02M K2HPO4 solution at 37°C, these glasses reacted to form a carbonate-substituted hydroxyapatite (c-HA) on their surfaces, indicating their bioactive potential. The conversion rate to c-HA was controlled by adjusting the B2O3/SiO2 ratio in the glass composition. The results indicate the potential application of the borate-based bioactive glass as scaffold materials for bone tissue engineering.
A. Yao et al., "In Vitro Bioactive Characteristics of Borate-based Glasses with Controllable Degradation Behavior," Journal of the American Ceramic Society, American Ceramic Society, Jan 2007.
The definitive version is available at http://dx.doi.org/10.1111/j.1551-2916.2006.01358.x
Materials Science and Engineering
University of Missouri--Rolla
Keywords and Phrases
Bioactive Glasses; Biomedical Application; Controllable Degradation
Article - Journal
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