Title

In Vitro Bioactive Characteristics of Borate-based Glasses with Controllable Degradation Behavior

Abstract

Silicate-based bioactive glasses undergo incomplete conversion to a calcium phosphate material after in vivo implantation, which severely limits their biomedical application. In this communication, novel borate-based glasses with controllable degradation behavior were developed and their bioactive potential was investigated in vitro. when immersed in a 0.02M K2HPO4 solution at 37°C, these glasses reacted to form a carbonate-substituted hydroxyapatite (c-HA) on their surfaces, indicating their bioactive potential. The conversion rate to c-HA was controlled by adjusting the B2O3/SiO2 ratio in the glass composition. The results indicate the potential application of the borate-based bioactive glass as scaffold materials for bone tissue engineering.

Department(s)

Materials Science and Engineering

Sponsor(s)

University of Missouri--Rolla

Keywords and Phrases

Bioactive Glasses; Biomedical Application; Controllable Degradation

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2007 American Ceramic Society, All rights reserved.


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