Title

Effect of Scavengers in Acidolytic Cleavage of Cys(acm)-containing Peptides from Solid Support: Isolation of an Ethanedithiol Disulfide Adduct

Abstract

Acidolytic cleavage of C-terminal Cys(Acm)-containing tripeptides from the Wang (HMP) resin can lead to partial deprotection of the Acm group and subsequent disulfide formation. The presence of water and the type of scavenger used in the cocktail mixture were found to play a role in the extent of these impurities formed.

Department(s)

Mathematics and Statistics

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1996 Elsevier, All rights reserved.

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