Effect of Scavengers in Acidolytic Cleavage of Cys(acm)-containing Peptides from Solid Support: Isolation of an Ethanedithiol Disulfide Adduct
Acidolytic cleavage of C-terminal Cys(Acm)-containing tripeptides from the Wang (HMP) resin can lead to partial deprotection of the Acm group and subsequent disulfide formation. The presence of water and the type of scavenger used in the cocktail mixture were found to play a role in the extent of these impurities formed.
P. R. Singh et al., "Effect of Scavengers in Acidolytic Cleavage of Cys(acm)-containing Peptides from Solid Support: Isolation of an Ethanedithiol Disulfide Adduct," Tetrahedron Letters, Elsevier, Jan 1996.
The definitive version is available at https://doi.org/10.1016/0040-4039(96)00614-4
Mathematics and Statistics
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