Effect of Scavengers in Acidolytic Cleavage of Cys(acm)-containing Peptides from Solid Support: Isolation of an Ethanedithiol Disulfide Adduct

Author

Prahlad R. Singh
Milind Rajopadhye
Stephen L. Clark, Missouri University of Science and TechnologyFollow
Neal E. Williams

Abstract

Acidolytic cleavage of C-terminal Cys(Acm)-containing tripeptides from the Wang (HMP) resin can lead to partial deprotection of the Acm group and subsequent disulfide formation. The presence of water and the type of scavenger used in the cocktail mixture were found to play a role in the extent of these impurities formed.

Recommended Citation

P. R. Singh et al., "Effect of Scavengers in Acidolytic Cleavage of Cys(acm)-containing Peptides from Solid Support: Isolation of an Ethanedithiol Disulfide Adduct," Tetrahedron Letters, Elsevier, Jan 1996.

The definitive version is available at https://doi.org/10.1016/0040-4039(96)00614-4

Department(s)

Mathematics and Statistics

International Standard Serial Number (ISSN)

0040-4039

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1996 Elsevier, All rights reserved.

Publication Date

01 Jan 1996