Masters Theses

Title

N-Acetylcystein amide protects against methamphetamine-induced oxidative stress in human brain endothelial cells

Abstract

"Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog that causes degeneration of the dopaminergic system in mammals and subsequent oxidative stress. In our present study, we have used immortalized human brain microvascular endothelial cells to test whether METH induces oxidative stress in vitro and the ability of a new antioxidant, N-Acetylcystein amide (NACA), to prevent METH-induced oxidative stress"--Abstract, leaf iii.

Advisor(s)

Ercal, Nuran

Committee Member(s)

Ma, Yinfa
Huang, Yue-wern

Department(s)

Chemistry

Degree Name

M.S. in Chemistry

Publisher

Missouri University of Science and Technology

Publication Date

Fall 2008

Pagination

ix, 52 leaves

Note about bibliography

Includes bibliographical references (leaves 151-153).

Rights

© 2008 Xinsheng Zhang, All rights reserved.

Document Type

Thesis - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Methamphetamine -- Physiological effect
Nervous system -- Degeneration -- Pathophysiology
Oxidative stress

Thesis Number

T 9451

Print OCLC #

316196920

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b6665295~S5

This document is currently not available here.

Share

 
COinS