Masters Theses

Abstract

"Thyroglobulin was digested with trypsin. An iodotyrosyl-containing peptide was isolated from tryptic digests by a combination of electrophoresis and paper chromatography. The amino acid sequence of this peptide was determined by applying the Edman degradation and by using the proteolytic enzyme, carboxypeptidase A. The sequence of this peptide is: NH₂-Ala-Ile(Leu)-Ala-Ser-Phe-Gly-Asp-Tyr-Glu-Phe-COOH The importance of the position of the tyrosyl residue which is iodinated to form monoiodotyrosine (MIT) , diiodotyrosine (DIT) , and thyroxine (T₄) is considered in connection with the structure-activity relationship of the protein"--Abstract, page ii.

Advisor(s)

Nicholson, Larry M.

Committee Member(s)

Gale, Nord L.
Siehr, Donald J.

Department(s)

Chemistry

Degree Name

M.S. in Chemistry

Publisher

University of Missouri--Rolla

Publication Date

1970

Pagination

viii, 49 pages

Note about bibliography

Includes bibliographical references (pages 75-77).

Rights

© 1970 Pai-Chun Chiang, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Library of Congress Subject Headings

Amino acid sequence
Amino acids -- Analysis
Peptides -- Analysis

Thesis Number

T 2468

Print OCLC #

6028237

Electronic OCLC #

864828876

Included in

Chemistry Commons

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