Masters Theses

Title

Effects of a newly synthesized thiol antioxidant on doxorubicin-induced oxidative stress

Author

Rong Shi

Keywords and Phrases

N-acetylcysteine amide (NACA)

Abstract

"Doxorubicin is a representative of the class of quinoid anthracycline antitumor drugs that are most widely used in cancer chemotherapy. Unfortunately, long-term treatment by doxorubicin is limited by cardiotoxicity due to generation of reactive oxygen species (ROS). This study was conducted to determine the effects of a new thiol antioxidant, N-acetylcysteine amide (NACA), on doxorubicin-induced cardiotoxicity"--Abstract, leaf iii.

Advisor(s)

Ercal, Nuran
Huang, Yue-wern

Committee Member(s)

Aronstam, Robert
Sinn, Ekkehard

Department(s)

Chemistry

Degree Name

M.S. in Chemistry

Publisher

University of Missouri--Rolla

Publication Date

Fall 2006

Pagination

ix, 61 leaves

Note about bibliography

Includes bibliographical references (page 26).

Rights

© 2006 Rong Shi, All rights reserved.

Document Type

Thesis - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Antineoplastic agents -- Toxicology
Antioxidants
Doxorubicin
Oxidative stress

Thesis Number

T 9114

Print OCLC #

173611429

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b5999603~S5

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