Masters Theses

Title

A high-performance amperometric biosensor system utilizing electrolytic gas bubbles

Alternative Title

High performance amperometric biosensor system utilizing electrolytic gas bubbles

Author

Jongwon Park

Abstract

"Most of the biochemical sensors exhibit instabilities such as baseline drift and sensitivity degradation. On on-demand in situ self-diagnosis and self-calibration functionality of biochemical sensors is indispensable for continuous and reliable monitoring. An on-chip electrochemical actuation method (water electrolysis) was employed to achieve this novel functionality. New integrated microfluidic systems are proposed for intelligent glucose and lactate monitoring. The oxygen microenvironment created by the electrolytic bubbles provides novel functionalities to glucose and lactate sensors: the one-point in situ self-calibration (zero-point), extension of dynamic range, and increase in sensitivity. The properties of electrolytically generated gas bubble were first investigated with a commercial fiber optic oxygen sensor. A microsystem including a fluidic structure and electrolysis electrodes is prepared by microfabrication technologies. A thick photoresist was used to prepare a template for the molding process of a polydimethylsiloxane (PDMS) cover layer to define the fluidic structure. The electrode substrate was a silicon wafer with a silicon nitride layer coating. The controlled oxygen microenvironment effectively manipulated the sensor responses. This electrochemically-driven fluidic biosensor system appears to be a promising platform of minimally invasive biosensing devices or extracorporeal devices for continuous monitoring due to its simple and miniaturized structure"--Abstract, leaf iii.

Department(s)

Electrical and Computer Engineering

Degree Name

M.S. in Electrical Engineering

Publisher

University of Missouri--Rolla

Publication Date

Fall 2005

Pagination

viii, 40 leaves

Rights

© 2005 Jongwon Park, All rights reserved.

Document Type

Thesis - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Biosensors
Bubbles
Conductometric analysis

Thesis Number

T 8905

Print OCLC #

72439759

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b5664767~S5

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