Masters Theses

Abstract

"Bioactive glasses are promising materials for bone scaffolds due to their ability to assist in tissue regeneration. When implanted in vivo, bioactive glasses can convert to hydroxyapatite, the main mineral constituent of human bone and form a strong bond with the surrounding tissues, thus providing an advantage over polymer scaffold materials. Bone scaffold fabrication using additive manufacturing techniques like selective laser sintering (SLS) provide control over pore interconnectivity during the fabrication of scaffold, which helps in mimicking human trabecular bone. 13-93 glass, a third-generation bioactive material designed to accelerate the body's natural ability to heal itself, was used in the research described herein to fabricate bone scaffolds using SLS process. 13-93 bioactive glass mixed with stearic acid (as the polymer binder) by ball milling was used as the powder feedstock for the SLS machine. The fabricated green scaffolds underwent binder burnout to remove the stearic acid binder and were then sintered at temperatures between 675ʻC and 700ʻC. The sintered scaffolds had pore sizes ranging from 300 µm to 800 µm with 50% apparent porosity and a maximum compressive strength of 23.6 MPa, which is the highest reported for controlled porosity scaffolds fabricated with bioactive glasses using the SLS process. The MTT labeling experiment and measurements of MTT formazan formation are evidence that the rough surface of SLS scaffolds, as seen in scanning electron microscope (SEM) images, provides a cell-friendly surface capable of supporting robust cell growth"--Abstract, page iv.

Advisor(s)

Leu, M. C. (Ming-Chuan)

Committee Member(s)

Liou, Frank W.
Hilmas, Greg

Department(s)

Mechanical and Aerospace Engineering

Degree Name

M.S. in Mechanical Engineering

Sponsor(s)

Missouri University of Science and Technology. Intelligent Systems Center
National Science Foundation (U.S.)

Research Center/Lab(s)

Intelligent Systems Center

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2011

Journal article titles appearing in thesis/dissertation

  • Fabrication of 13-93 bioactive glass scaffolds for bone tissue engineering using indirect selective laser sintering
  • Direct selective laser sintering of 13-93 bioactive glass

Pagination

xi, 77 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2011 Krishna Chaitanya Reddy Kolan, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Subject Headings

Bone regeneration
Bones -- Growth
Glass in medicine
Hydroxyapatite
Tissue engineering

Thesis Number

T 9828

Print OCLC #

792756723

Electronic OCLC #

908763790

Link to Catalog Record

Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.

http://merlin.lib.umsystem.edu/record=b8544175~S5

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