Masters Theses

Title

Influence of S-nitrosylation on muscarinic acetylcholine receptors

Keywords and Phrases

Methylscopolamine

Abstract

"Muscarinic acetylcholine receptors possess a conserved pair of extracellular cysteines which form a disulfide bond between the 1st and the 2nd extracellular loop. Previous work has shown that the disulfide bond forming cysteines influence ligand binding and receptor interaction with transducer proteins. Nitric oxide (NO) has multiple roles in cellular signaling. One mechanism for NO activity is the nitrosylation of protein sulfhydryl groups. Accordingly, in the present studies the role of the nitric oxide generating compound sodium nitroprusside on ligand binding to muscarinic receptors of rat brainstem was studied"--Abstract, leaf iii.

Advisor(s)

Aronstam, Robert

Committee Member(s)

Shannon, Katie
Ercal, Nuran

Department(s)

Biological Sciences

Degree Name

M.S. in Applied and Environmental Biology

Publisher

University of Missouri--Rolla

Publication Date

Spring 2007

Pagination

x, 57 leaves

Note about bibliography

Includes bibliographical references.

Rights

© 2007 Pradnya Pandurang Patil, All rights reserved.

Document Type

Thesis - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Cellular signal transduction
G proteins
Muscarinic receptors

Thesis Number

T 9130

Print OCLC #

173309875

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b5973583~S5

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