We propose a novel method to overcome significant problems of baseline drift and sensitivity degradation in amperometric biosensors based on oxidase enzyme reactions. A novel glucose microsensor with a built-in electrochemical oxygen manipulation microsystem is introduced to demonstrate three novel functionalities; one-point in situ self-calibration (zero-point), broadening of dynamic range and increase in sensitivity. The influence of electrochemically generated oxygen microenvironment on the sensor output within a fluidic structure is investigated.
C. Kim and J. Park, "Influence of Oxygen Microenvironment on Microfluidic Glucose Sensor Performance," Proceedings of the 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, 2005, Institute of Electrical and Electronics Engineers (IEEE), Jan 2005.
The definitive version is available at http://dx.doi.org/10.1109/MMB.2005.1548374
3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, 2005
Electrical and Computer Engineering
Chemical and Biochemical Engineering
National Science Foundation (U.S.)
Keywords and Phrases
Electrolysis; Hydrogen; Oxygen
Article - Conference proceedings
© 2005 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.