Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue, a novel solid-state glucose oxidase-coupled amperometric biosensor with integrated electrochemical actuation system has been designed and validated. There are two key components of the proposed glucose biosensor: solid-state GOD-coupled thin-lm amperometric sensing element andO 2 depleting/saturating built-in electrochemical actuator. The actuator can be used to accomplish in-situ 1-point self-calibration by depleting O 2 (i.e., by simulating glucose-free environment). Also, it can be used at the same time to extend the proposed sensor''s linear detection range by in ating O 2 (i.e., by enhancing glucose sensitivity). A prototype sensor was fabricated and a series of lab experiments was conducted. Collected data assures that the proposed sensor effectively establishes the zero calibration point and signi cantly enhances its measurement sensitivity and con dence.

Meeting Name

2005 IEEE Instrumentationand Measurement Technology Conference


Electrical and Computer Engineering

Second Department

Chemical and Biochemical Engineering

Keywords and Phrases

Actuator; GOD(Glucose Oxidase); Glucose Measurement; Solid-State Biosensor; Thin-Lm Amperometric Sensor

Document Type

Article - Conference proceedings

Document Version

Final Version

File Type





© 2005 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.