Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. To address this deficiency, a novel needle-type biosensor system with fully automated operations is being developed, in which a novel oxidase-coupled amperometric sensor with oxygen depleting/generating actuator is interfaced with an electrochemical instrument and a perfusion system. Labview virtual instrument has been also developed to oversee the automatic control of the prototype sensor. Using the proposed system, a large amount of data can be rapidly collected for more effective sensor characterization and more advanced sensor designs. Autonomous and continuous sensing and self-calibration with minimal human intervention is also envisioned.
Y. Yellambalase et al., "Automated Oxidase-Coupled Amperometric Microsensor with Integrated Electrochemical Actuation System for Continuous Sensing of Saccharoids," Proceedings of the IEEE Instrumentation and Measurement Technology Conference (2006, Sorrento, Italy), pp. 1795-1800, Institute of Electrical and Electronics Engineers (IEEE), Apr 2006.
The definitive version is available at http://dx.doi.org/10.1109/IMTC.2006.328252
IEEE Instrumentation and Measurement Technology Conference: IMTC (2006: Apr. 24-27, Sorrento, Italy)
Electrical and Computer Engineering
National Science Foundation (U.S.)
Keywords and Phrases
Actuator; Automation; Calibration; Continuous Calibration/Sensing; GOD (Glucose Oxidase); LOD (Lactate Oxidase); LabView; Needle Based Amperometric Sensor; Solid-State Biosensor; Water Electrolysis; Continous Calibration; Integrated Electrochemical Actuation; Amperometric Sensors; Biosensors; Diagnosis; Microsensors
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Article - Conference proceedings
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