"A theory is constructed to describe quantitatively the dynamic behavior of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes.
Dynamic and spatially multi-dimensional mathematical models of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes are constructed and analyzed for (a) bulk freeze-drying in trays, and (b) lyophilization in vials. The models account for the removal of free and bound (sorbed) water and could also provide the geometric shape of the moving interface and its position. By using a pilot freeze-dryer, experimental data for the freeze-drying of Cloxacillin Monosodium Salt and Skim Milk in trays are obtained. The comparison of the theoretical results with the experimental data shows that the agreement between experiment and theory is good.
The theoretical models presented in this work could be used to develop design conditions, operating conditions, and control strategies that could provide high drying rates and high quality assurance for the pharmaceutical material being freeze-dried"--Abstract, page v.
Liapis, Athanasios I.
Crosser, Orrin K.
Johnson, James W., 1930-2002
Reed, X. B., Jr.
Avula, Xavier J. R.
Ho, C. Y. (Chung You), 1933-1988
Chemical and Biochemical Engineering
Ph. D. in Chemical Engineering
National Science Foundation (U.S.)
North Atlantic Treaty Organization. Scientific Affairs Division
Criofarma-Freeze Drying Equipment
University of Missouri--Rolla
Journal article titles appearing in thesis/dissertation
- Freeze drying
- A theory for the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes: Comparison between experimental data and theory
- Freeze-drying of pharmaceutical crystalline and amorphous solutes in vials: Dynamic multi-dimensional models of the primary and secondary drying stages and qualitative features of the moving interface
xii, 238 pages
© 1994 Roberto Bruttini, All rights reserved.
Dissertation - Restricted Access
Library of Congress Subject Headings
Freeze-drying -- Research
Freeze-drying -- Mathematical models
Drying -- Mathematical models
Interfaces (Physical sciences) -- Mathematical models
Print OCLC #
Electronic OCLC #
Link to Catalog RecordElectronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library. http://laurel.lso.missouri.edu/record=b1978590~S5
Bruttini, Roberto, "Analytical, modelling, and experimental studies of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes" (1994). Doctoral Dissertations. 633.