Doctoral Dissertations

Title

A study of the beneficial role of thiol antioxidant supplementation in various forms of glutathione deficiency

Abstract

"Oxidative stress plays a major role in the pathology of numerous disorders afflicting humans, ranging from neurodegenerative diseases, to cancer, and heavy metal toxicity. Scientists are on the constant lookout for new and better antioxidants that have the ability to slow, if not stop the harmful degenerative effects of free radicals in oxidative stress related disorders. Both synthetic and naturally occurring compounds are being constantly screened for their antioxidant properties. This study attempted to evaluate the abilities of a thiol antioxidant, N-Acetylcysteine amide (NACA), to protect cells from the harmful effects of gluthathione depletion in two different models of oxidative stress"--Abstract, leaf iii.

Advisor(s)

Ercal, Nuran
Lutz, Paula Marcellus, 1954-

Committee Member(s)

Sotiriou-Leventis, Lia
Sinn, Ekkehard
Aronstam, Robert

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Sponsor(s)

National Institute of Health (U.S.)

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2009

Journal article titles appearing in thesis/dissertation

  • Tert-butyl hydroperoxide induced oxidative damage in ARPE-19 cells and protection by N-Acetylcysteine amide
  • Antioxidant status of cultured fibroblasts from patients with glutathione synthetase deficiency and benefits of thiol supplementation
  • Characterization of antioxidant status of mice heterozygous for glutathione synthetase

Pagination

xiii, 115 leaves

Note about bibliography

Includes bibliographical references (leaves 102-114).

Rights

© 2009 Linu Sara Abraham, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Antioxidants -- Therapeutic use
Oxidative stress
Thiols

Thesis Number

T 9507

Print OCLC #

551147642

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b7429843~S5

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