Doctoral Dissertations

Title

Investigation of in vitro and in vivo radioprotection by a newly-designed thiol antioxidant, n-acetylcysteine amide (NACA)

Author

Wei Wu

Abstract

"The nuclear accidents and the threat of a terrorist nuclear attack have raised awareness that high-dose total body irradiation may occur. The systemic damage observed following irradiation is partially due to the overproduction of reactive oxygen species (ROS) which disrupt the delicate pro-oxidant/antioxidant balance of tissues leading to protein, lipid, and DNA oxidation. Thiol supplementation to maintain tissue redox balance has been studied by various researchers...Our purpose is to explore the radio-protective effects of the novel cell-permeating thiol antioxidant, NACA, and thereby to explain the mechanism that provides protection against radiation to cells and animals"--Abstract, leaf iii.

Advisor(s)

Ercal, Nuran

Committee Member(s)

Ma, Yinfa
Matthews, Richard H.
Frank, Ronald L.
Sinn, Ekkehard

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Publisher

University of Missouri--Rolla

Publication Date

Fall 2006

Pagination

xii, 126 leaves

Note about bibliography

Includes bibliographical references.

Rights

© 2006 Wei Wu, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Antioxidants
Oxidative stress
Radiation-protective agents
Thiols

Thesis Number

T 9051

Print OCLC #

168588224

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b5946909~S5

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