Investigation of in vitro and in vivo radioprotection by a newly-designed thiol antioxidant, n-acetylcysteine amide (NACA)
"The nuclear accidents and the threat of a terrorist nuclear attack have raised awareness that high-dose total body irradiation may occur. The systemic damage observed following irradiation is partially due to the overproduction of reactive oxygen species (ROS) which disrupt the delicate pro-oxidant/antioxidant balance of tissues leading to protein, lipid, and DNA oxidation. Thiol supplementation to maintain tissue redox balance has been studied by various researchers...Our purpose is to explore the radio-protective effects of the novel cell-permeating thiol antioxidant, NACA, and thereby to explain the mechanism that provides protection against radiation to cells and animals"--Abstract, leaf iii.
Matthews, Richard H.
Frank, Ronald L.
Ph. D. in Chemistry
University of Missouri--Rolla
xii, 126 leaves
© 2006 Wei Wu, All rights reserved.
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Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.http://laurel.lso.missouri.edu/record=b5946909~S5
Wu, Wei, "Investigation of in vitro and in vivo radioprotection by a newly-designed thiol antioxidant, n-acetylcysteine amide (NACA)" (2006). Doctoral Dissertations. 1708.