Doctoral Dissertations

Title

Adsorption of diblock polypeptides at solid/liquid interfaces

Alternative Title

Adsorption of diblock polypeptides at solid liquid interfaces

Abstract

"Protein/peptide adsorption at solid/liquid interfaces is significantly affected by hydrophobic and electrostatic forces.l Dynamic light scattering (DLS) and isotherms were used for adsorption of diblock co-polypeptides with different properties on negatively charged poly(styrene) (PS) nanospheres. These peptides differ in their hydrophobicity and charge. Peptides with one hydrophilic and one non-polar (alanine) or with both hydorphilic blocks with opposite charges (glutamic acid and lysine) were chemically synthesized. Adsorption experiments were performed in aqueous solution, water/methanol and water/glycerol mixtures at different pHs to study both these effects. It was found that electrostatic interactions between the peptide and the surface are more dominant"--Abstract, leaf iv.

Department(s)

Chemical and Biochemical Engineering

Degree Name

Ph. D. in Chemical Engineering

Publisher

University of Missouri--Rolla

Publication Date

Summer 2005

Journal article titles appearing in thesis/dissertation

  • Adsorption of diblock polypeptides on polystyrene latex
  • Effect of solvent composition on the adsorption of diblock polypeptides on polystyrene latex
  • Adsorption of random coils and helices at solid/liquid interfaces: a Monte Carlo study

Pagination

xii, 126 leaves

Note about bibliography

Includes bibliographical references.

Rights

© 2005 Riteshkumar Jain, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Library of Congress Subject Headings

Peptides
Polystyrene
Adsorption
Monte Carlo method

Thesis Number

T 8829

Print OCLC #

69402918

Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

http://laurel.lso.missouri.edu/record=b5544626~S5

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