Title

Co-Restoring Multimodal Microscopy Images

Abstract

We propose a novel microscopy image restoration algorithm capable of co-restoring Phase Contrast and Differential Interference Contrast (DIC) microscopy images captured on the same cell dish simultaneously. Cells with different phase retardation and DIC gradient signals are restored into a single image without the halo artifact from phase contrast or pseudo 3D shadow-casting effect from DIC. The co-restoration integrates the advantages of two imaging modalities and overcomes the drawbacks in single-modal image restoration. Evaluated on a datasets of five hundred pairs of phase contrast and DIC images, the co-restoration demonstrates its effectiveness to greatly facilitate the cell image analysis tasks such as cell segmentation and classification.

Department(s)

Computer Science

Keywords and Phrases

Algorithms; Cells; Classification (of Information); Cytology; Image Reconstruction; Image Segmentation; Medical Computing; Restoration; Cell Image Analysis; Cell Segmentation; Differential Interference Contrast Microscopy; Imaging Modality; Microscopy Images; Multimodal Microscopy; Phase Contrasts; Phase Retardation; Medical Imaging

International Standard Book Number (ISBN)

9783319245737

International Standard Serial Number (ISSN)

0302-9743

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2015 Springer Verlag, All rights reserved.

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