Protein domains typically correspond to major functional sites of a protein. Therefore, determining similarity between domains can aid in the comparison of protein functions, and can provide a basis for grouping domains based on function. One strategy for comparing domain similarity and domain-protein similarity is to use similarity measurements of annotation terms from the Gene Ontology (GO). In this paper five methods are analyzed in terms of their usefulness for comparing domains, and comparing domains to proteins based on GO terms.
L. M. Guntly et al., "Determining Domain Similarity and Domain-Protein Similarity using Functional Similarity Measurements of Gene Ontology Terms," Proceedings of the IEEE 7th International Symposium on Bioinformatics and Bioengineering (2007, Boston, MA), pp. 1209-1213, Institute of Electrical and Electronics Engineers (IEEE), Oct 2007.
The definitive version is available at http://dx.doi.org/10.1109/BIBE.2007.4375717
IEEE 7th International Symposium on Bioinformatics and Bioengineering (2007: Oct. 14-17, Boston, MA)
Keywords and Phrases
Gene Ontology; Domain; Protein
Article - Conference proceedings
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