New Nanomedicine Approaches Using Gold-thioguanine Nanoconjugates as Metallo-Ligands
Gold-thioguanine nanoconjugates (AuNP-TG) of size 3-4 nm were synthesized and the ratio between gold and 6-thioguanine (TG) was estimated as ~1:1.5 using a cyanide digestion method and confirmed by flame atomic absorption spectroscopic analysis. AuNP-TG constructs showed high in vitro stability under different pH conditions and biologically relevant solutions for a period of 24 h. Reaction of AuNP-TG with europium or platinum salts resulted in the formation of organized self-assembled metallo-networks.
L. Sleightholm et al., "New Nanomedicine Approaches Using Gold-thioguanine Nanoconjugates as Metallo-Ligands," Inorganica Chimica Acta, vol. 372, no. 1, pp. 333-339, Elsevier, Jun 2011.
The definitive version is available at http://dx.doi.org/10.1016/j.ica.2011.01.065
Keywords and Phrases
Europium; Gold nanoparticles; Ligands; Nanomedicine; Platinum; Thioguanine
International Standard Serial Number (ISSN)
Article - Journal
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