Title

New Nanomedicine Approaches Using Gold-thioguanine Nanoconjugates as Metallo-Ligands

Abstract

Gold-thioguanine nanoconjugates (AuNP-TG) of size 3-4 nm were synthesized and the ratio between gold and 6-thioguanine (TG) was estimated as ~1:1.5 using a cyanide digestion method and confirmed by flame atomic absorption spectroscopic analysis. AuNP-TG constructs showed high in vitro stability under different pH conditions and biologically relevant solutions for a period of 24 h. Reaction of AuNP-TG with europium or platinum salts resulted in the formation of organized self-assembled metallo-networks.

Department(s)

Chemistry

Keywords and Phrases

Europium; Gold nanoparticles; Ligands; Nanomedicine; Platinum; Thioguanine

International Standard Serial Number (ISSN)

201693

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2011 Elsevier, All rights reserved.


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