Title

Nanoscale Sensor Design via in Situ Labeling of Gold Nanoparticles onto Protein Scaffolds

Abstract

A one-step method for synthesis of bioconjugated gold nanoparticles is reported. A non-toxic and biocompatible phosphorus based reducing agent was used for reduction of gold (III) and formation of nanoparticles. Physicochemical properties of protein-A stabilized gold nanoparticls were investigated. Result of immunoassay experiments confirmed the potential of the synthesized anti-protein-A conjugated gold nanoparticles for use as a simple and inexpensive test for quantitative screening of protein-A samples.

Department(s)

Chemistry

Keywords and Phrases

Gold Nanoparticles; In-situ; Nanoscale sensors; One-step methods; Physicochemical property; Quantitative screening; Antibodies; Gold; Gold compounds; Phosphorus; Sensors; Antibody; Nanoparticles; Protein a.; SensorNanoparticles; gold; metal nanoparticle; protein, article; chemistry; nanotechnology; Gold; Metal Nanoparticles; Nanotechnology; Proteins

International Standard Serial Number (ISSN)

15334880

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2010 American Scientific Publishers, All rights reserved.


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