Captopril as an Antioxidant in Lead-exposed Fischer 344 Rats
1 Recent studies suggest that lead induces oxidative stress in various tissues. 2 Captopril ([2S]-1-[3-mercapto-2-methylpropionyl]-L-proline), an angiotensin-converting enzyme inhibitor, is a well-known antihypertensive agent and is also believed to function as an antioxidant. 3 In the present study the antioxidant effect of captopril on lead-induced oxidative stress was studied in Fischer 344 rats. Their liver, brain and kidneys were assayed for glutathione (GSH), glutathione disulfide (GSSG), malondialdehyde concentrations, and catalase activities. The results from animals treated with captopril were compared to results of control and lead-exposed non-treated groups. 4 The captopril-treated samples showed higher GSH:GSSG ratios in the liver, brain and kidneys, as well as slightly decreased malondialdehyde concentrations. The catalase activity was not significantly affected.
N. Ercal et al., "Captopril as an Antioxidant in Lead-exposed Fischer 344 Rats," Human and Experimental Toxicology, SAGE Publications, Jan 1999.
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