Title

N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines

Abstract

Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF3) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.

Department(s)

Chemistry

Keywords and Phrases

Aldimines; Catalysis; Imidazolium; N-Heterocyclic carbene; TMSCF3; Trifluoromethylation

International Standard Serial Number (ISSN)

1022-5528; 1572-9028

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2018 Springer US, All rights reserved.

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