Review: Physicochemical Structure Effects on Metal Oxide Nanoparticulate Cytotoxicity
The utility of physicochemical surface characterization as a tool for understanding surface structure-property relationships governing fourth period metal transition metal oxide nanoparticulate (TiO2, Cr2O3, Mn2O3, Fe2O3, NiO, CuO and ZnO) cytotoxicity is shown. An overview of surface structural probes of the material isoelectric point and relative number of binding sites on the oxide surface is presented, relating these factors with observed trends in toxicity. A tutorial is given explaining the strategy used to probe the solid surface, and correlating nanoparticulate physicochemical structure with cytotoxicity. Insight into the role of nanoparticle (NP) surface charge and relative number of binding sites are applied for interpreting two case studies showing (1) enhanced toxicity of TiO2 NPs (the least toxic NPs in the series), and (2) mitigating potent toxicity of ZnO NPs.
C. C. Chusuei et al., "Review: Physicochemical Structure Effects on Metal Oxide Nanoparticulate Cytotoxicity," Recent Progress in Colloid and Surface Chemistry with Biological Applications ( ACS Symposium Series), vol. 1214, pp. 137-155, American Chemical Society (ACS), Jan 2015.
The definitive version is available at https://doi.org/10.1021/bk-2015-1215.ch008
Keywords and Phrases
Bins; Colloid Chemistry; Cytotoxicity; Manganese; Metallic Compounds; Metals; Surface Chemistry; Toxicity; Transition Metal Compounds; Transition Metals; Zinc Oxide; Iso-Electric Points; Metal Transition; Nano Particulates; Solid Surface; Structural Probes; Structure Effect; Structure Property Relationships; Surface Characterization; Binding Sites
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