Review: Physicochemical Structure Effects on Metal Oxide Nanoparticulate Cytotoxicity

Abstract

The utility of physicochemical surface characterization as a tool for understanding surface structure-property relationships governing fourth period metal transition metal oxide nanoparticulate (TiO2, Cr2O3, Mn2O3, Fe2O3, NiO, CuO and ZnO) cytotoxicity is shown. An overview of surface structural probes of the material isoelectric point and relative number of binding sites on the oxide surface is presented, relating these factors with observed trends in toxicity. A tutorial is given explaining the strategy used to probe the solid surface, and correlating nanoparticulate physicochemical structure with cytotoxicity. Insight into the role of nanoparticle (NP) surface charge and relative number of binding sites are applied for interpreting two case studies showing (1) enhanced toxicity of TiO2 NPs (the least toxic NPs in the series), and (2) mitigating potent toxicity of ZnO NPs.

Department(s)

Chemistry

Second Department

Biological Sciences

Keywords and Phrases

Bins; Colloid Chemistry; Cytotoxicity; Manganese; Metallic Compounds; Metals; Surface Chemistry; Toxicity; Transition Metal Compounds; Transition Metals; Zinc Oxide; Iso-Electric Points; Metal Transition; Nano Particulates; Solid Surface; Structural Probes; Structure Effect; Structure Property Relationships; Surface Characterization; Binding Sites

International Standard Book Number (ISBN)

978-0-8412-3120-7; 978-0-8412-3119-1

International Standard Serial Number (ISSN)

0097-6156; 1947-5918

Electronic OCLC #

931861396

Print OCLC #

931860745

Document Type

Book - Chapter

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2015 American Chemical Society (ACS), All rights reserved.

Publication Date

01 Jan 2015

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