Antioxidant Therapy in Alzheimer's Disease: Theory and Practice

Author

Gjumrakch Aliev
Mark E. Obrenovich
Prakash Reddy, Missouri University of Science and TechnologyFollow
Justin C. Shenk
Paula I. Moreira
Akihiko Nunomura
Xiongwei Zhu
Mark A. Smith
George Perry

Abstract

Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

Recommended Citation

G. Aliev et al., "Antioxidant Therapy in Alzheimer's Disease: Theory and Practice," Mini-Reviews in Medicinal Chemistry, vol. 8, no. 13, pp. 1395 - 1406, Bentham Science Publishers, Nov 2008.

The definitive version is available at https://doi.org/10.2174/138955708786369582

Department(s)

Chemistry

Keywords and Phrases

antioxidant; scavenger; Alzheimer disease; animal; brain; drug effect; genetics; human; metabolism; oxidative stress; pathology; Free Radical Scavengers

International Standard Serial Number (ISSN)

1389-5575

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2008 Bentham Science Publishers, All rights reserved.

Publication Date

01 Nov 2008