Title

A Rebuttal to "A Comment to 'Normalization of Urinary Pteridines by Urine Specific Gravity for Early Cancer Detection' [Clin. Chim. Acta 435 (2014) 42-47]"

Abstract

We really appreciate the comments from Drs. Reibnegger and Fuchs regarding our recent publication "Normalization of urinary pteridines by urine specific gravity for early cancer detection [Clin. Chim. Acta 435 (2014) 42-47]". In their letter, Drs. Reibnegger and Fuchs identify several potential concerns regarding our recent publication that evaluated the normalization performance of urine specific gravity (USG) and urinary creatinine with respect to the diagnostic properties of selected pteridines in discerning aggressive and benign breast cancers. Their letter not only provides unique insights that are both relevant and helpful to many researchers engaging in similar studies, but also provides a wonderful opportunity for us to address these potential concerns that may also be shared by other readers. We addressed all of the comments by Drs. Reibnegger and Fuchs in this letter.

Department(s)

Chemistry

Keywords and Phrases

Biopterin; Creatinine; Isoxanthopterin; Neopterin; Pteridine Derivative; Xanthopterin; Breast Cancer; Cancer Diagnosis; Capillary Electrophoresis; Diagnostic Value; Early Diagnosis; Fluorescence; High Performance Liquid Chromatography; Human; Malignant Neoplastic Disease; Mass Spectrometry; Renal System Parameters; Urine Level; Urine Specific Gravity

International Standard Serial Number (ISSN)

00098981

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2015 Elsevier, All rights reserved.


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