Biocompatibility of N3300 Series Polyurea Aerogels
MP4-X-T045, one type of cross-linked polyuea aerogel, has proved to have suitable biocompatibility and mechanical properties for artificial heart valve material. Using the same technique, a series of polyurea aerogels with various density (0.030–0.19 g/cm3) and pore size (~40 nm) were manufactured, and their biocompatibility were investigated. Plasma inflammatory response induced by aerogels was measured by anaphylatoxin C3a level using a commercial EIA assay after plasma incubation with aerogel samples for up to 24 hours. Platelet reaction to aerogels was measured by platelet surface CD62P expression using flow cytometry. Red blood cell response to aerogels were examined by hemolysis. after plasma incubation, aerogels were washed and potential protein deposits were eluted by SDS-Azide solution, which was examined by SDS-PAGE. the results demonstrated that these polyurea aerogels do not induce C3a over production, platelet activation, or hemolysis. There was also no significant deposition of plasma proteins on these aerogels. These results suggest that polyurea aerogels are compatible towards blood, though their structure and mechanical properties in response to plasma need to be further explored.
W. Yin et al., "Biocompatibility of N3300 Series Polyurea Aerogels," FASEB Journal, vol. 25, no. 1 Supplement, Federation of American Society of Experimental Biology, Jan 2011.
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