Title

Synthesis, Structure, Spectroscopy and Antitumor Activity of Hydroxy Naphthoquinone Thiosemicarbazone and Its Metal Complexes Against MCF-7 Human Breast Cancer Cell Line

Abstract

Coordinately unsaturated metal complexes of the stoichiometry [M(HL)Cl] and [Fe(HL)Cl 2].2H 2O have been isolated (where M=Cu(II), Ni(II), PD(II) and Pt(II); HL=tridentate anion of H 2L 3). The X-ray crystal structure for 4-hydroxy-3-methyl-1,2-naphthoquinone-1-thiosemicarbazone, 3 has been determined which crystallizes in space group P2 1/c, a = 7.430(3), b = 10.794(3), c = 17.216(5) Å, β =92.91(3)°. Z = 4, and have “E” configuration. The Cu(II) 3a, Ni(II) 3e, Pd(II) 3d and Pt(II) 3e complexes are found to possess square planar geometries, whereas Fe(III) complex 3b possesses a square pyramidal configuration. The in vitro activity of the synthesized compounds examined against human breast cancer cell line MCF-7 clearly indicates that metal complexation enhances antitumor activity, the highest being for the copper complex 3a.

Department(s)

Chemistry

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2002 National Institute of Science Communication and Information Resources (NISCAIR), All rights reserved.

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