Copper Complexes of Henna-sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB

Author

K. Shirisha
Jayendra Patole
Subhash B. Padhye
Ekkehard Sinn, Missouri University of Science and TechnologyFollow
Shishir Shishodia
Bharat Bhushan Aggarwal

Abstract

The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC 50 of 0.3 μM attributed to down regulation of NF-κB activation. © 2007 Bentham Science Publishers Ltd.

Recommended Citation

K. Shirisha et al., "Copper Complexes of Henna-sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB," Letters in Drug Design and Discovery, Bentham Science Publishers, Jan 2007.

The definitive version is available at https://doi.org/10.2174/157018007784620059

Department(s)

Chemistry

International Standard Serial Number (ISSN)

1570-1808

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2007 Bentham Science Publishers, All rights reserved.

Publication Date

01 Jan 2007