Abstract
Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl 2] followed by [Cu(TATSC)Cl 2] and the ligand in compariosn with cisplatin.
Recommended Citation
A. Murugkar et al., "Hormone Anchored Metal Complexes 1: Synthesis, Structure, Spectroscopy and in vitro Antitumor Activity of Testosterone Acetate: Thiosemicarbazone and its Metal Complexes," Metal-Based Drugs, Hindawi Publishing Corporation, Jan 1999.
The definitive version is available at https://doi.org/10.1155/MBD.1999.177
Department(s)
Chemistry
International Standard Serial Number (ISSN)
0793-0291
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 1999 Hindawi Publishing Corporation, All rights reserved.
Publication Date
01 Jan 1999
