Hormone Anchored Metal Complexes 1: Synthesis, Structure, Spectroscopy and in vitro Antitumor Activity of Testosterone Acetate: Thiosemicarbazone and its Metal Complexes
Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl 2] followed by [Cu(TATSC)Cl 2] and the ligand in compariosn with cisplatin.
A. Murugkar et al., "Hormone Anchored Metal Complexes 1: Synthesis, Structure, Spectroscopy and in vitro Antitumor Activity of Testosterone Acetate: Thiosemicarbazone and its Metal Complexes," Metal-Based Drugs, Hindawi Publishing Corporation, Jan 1999.
The definitive version is available at http://dx.doi.org/10.1155/MBD.1999.177
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© 1999 Hindawi Publishing Corporation, All rights reserved.