Title

Mixed-ligand Nickel(II) Thiosemicarbazone Complexes: Synthesis, Characterization and Biological Evaluation

Abstract

The syntheses and characterization of some new mixed-ligand nickel(II) complexes [Ni(L1)(PPh3)] (1), [Ni(L1)(Py)] (2), [Ni(L2)(PPh3)]·DMSO (3), [Ni(L 2)(Imz)] (4), [Ni(L3)(4-pic)] (5) and [Ni(L 3)2(μ-4,4′-byp)]·2DMSO (6) of three selected thiosemicarbazones the 4-(p-X-phenyl)thiosemicarbazones of salicylaldehyde (H2L1-3) (A, Scheme 1) are described in the present study, differing in the inductive effect of the substituent X (X = F, Br and OCH3), in order to observe its influence, if any, on the redox potentials and biological activity of the complexes. All the synthesized ligands and the metal complexes were successfully characterized by elemental analysis, IR, UV-Vis, NMR spectroscopy and cyclic voltammetry. The molecular structures of four mononuclear (1-3 and 5) and one dinuclear (6) Ni(II) complex have been determined by X-ray crystallography. The complexes have been screened for their antibacterial activity against Escherichia coli and Bacillus. The minimum inhibitory concentrations of these complexes and their antibacterial activities indicate that compound 4 is the potential lead molecule for drug designing. © 2012 Elsevier Ltd. All rights reserved.

Department(s)

Chemistry

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2013 Elsevier, All rights reserved.


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