Title

Use of Organic Cosolvents for Enhanced Leaching of HEMA/MAA Copolymers

Abstract

Leaching is a crucial step in production of polymeric biomaterials since it removes initiator, accelerator, solvents, unreacted monomer, oligomer and other byproducts remaining after polymerization; such small molecules are generally acknowledged to be a major reason for biological reaction to implanted polymers. This paper shows that the ionizable groups common to some classes of hydrogels can be manipulated to greatly enhance the leaching process over common methods wherein the outer water bath is periodically changed. The method uses organic cosolvents and inorganic salts to control the swelling during the leaching process.

Meeting Name

Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material (1985, Chicago, IL, USA)

Department(s)

Chemistry

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1985 American Chemical Society (ACS), All rights reserved.

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