Responsive Hydrogel as a Means of Preventing Calcification in Urological Prostheses
Editor(s)
Shalaby, W. and Hoffman, Allan S. and Ratner, Buddy D. and Horbett, Thomas A.
Abstract
Hydrogel prostheses made of poly(2-hydroxyethyl methacrylate), pHEMA, have demonstrated resistance to calcification in the urinary tract as reported. Hydrogels composed of pHEMA doped with small amounts of methacrylic acid and crosslinker demonstrate large volume changes between pH 6 and pH 7. The range of this collapse-like behavior is situated well within the normal range of urinary pH, electrolyte and urea content. Calcification in the urinary tract is not well understood but resistance of z-hydroxy methacrylate gels to calcification could quite reasonably depend upon the “active” nature of the gel. Accordingly, the physicochemical behavior of gels is as important to the design of urinary biomaterials as the simple chemical structure and physical properties.
Recommended Citation
E. C. Eckstein et al., "Responsive Hydrogel as a Means of Preventing Calcification in Urological Prostheses," Polymers as Biomaterials, Jan 1984.
The definitive version is available at https://doi.org/10.1007/978-1-4613-2433-1_23
Department(s)
Chemistry
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Publication Date
01 Jan 1984
