CD30⁺ Reversible Lymphoid Dyscrasia (Pseudolymphoma) Following HIDA Scintigraphy and the [Ring1]-[Ring2]-[C=O] Generalized Structure Hypothesis
To the Editor: Eighteen days after hepatobiliary iminodiacetic acid (HIDA) scintigraphy, an 81-year-old woman presented with pruritic, painful, discrete, tender papules in a generalized distribution (Fig 1). She noted onset of the eruption shortly after the HIDA scan. Biopsy specimen of 2 papules from the right thigh showed an infiltration of mitotically active lymphocytes (Fig 1, top inset) confined to the upper dermis. The lymphocytes were predominantly CD3+ T cells; occasional scattered CD20+ B cells were present. CD4 and CD8 were present in an approximately 2:1 ratio, and both cell types were noted within the epidermis. Small aggregates of large CD3+/CD30+ lymphocytes were present, comprising less than 25% of the lymphoid population (Fig 1, bottom inset). The histopathology and immunostaining supported a diagnosis of CD30+ plasma cell dyscrasia (pseudolymphoma).
R. K. Rader et al., "CD30⁺ Reversible Lymphoid Dyscrasia (Pseudolymphoma) Following HIDA Scintigraphy and the [Ring1]-[Ring2]-[C=O] Generalized Structure Hypothesis," Journal of the American Academy of Dermatology, Elsevier, Jan 2013.
The definitive version is available at https://doi.org/10.1016/j.jaad.2012.09.044
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