Efficient Chemoselective Oxidation of Phenylmethanols to Aldehydes with Iodosobenzene
Primary phenylmethanols are selectively and efficiently oxidized to the corresponding aldehydes by the system C6H5IO/(C 6H5)4PBr/CH2Cl2, T = 298 K under aerobic conditions. The use of the relatively stable iodosobenzene, an iodine(III) compound, in place of the usually employed and potentially explosive iodine(V) reagents, the easy work-up procedure, and the facile recycling of solvent and oxidant provides a convenient and environmentally benign oxidation method.
P. Paraskevopoulou et al., "Efficient Chemoselective Oxidation of Phenylmethanols to Aldehydes with Iodosobenzene," Monatshefte fur Chemie, vol. 136, no. 12, pp. 2035-2039, Springer Verlag, Dec 2005.
The definitive version is available at http://dx.doi.org/10.1007/s00706-005-0364-1
Keywords and Phrases
Alcohols; Chemoselectivity; Hypervalent Compounds; Iodine; Oxidations
International Standard Serial Number (ISSN)
Article - Journal
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