Gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor® and Pyridinium Polyhydrogen Fluoride
2,2-Diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving SelectfluorH and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.
P. Reddy et al., "Gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor® and Pyridinium Polyhydrogen Fluoride," Chemical Communications, Royal Society of Chemistry, Feb 2005.
The definitive version is available at http://dx.doi.org/10.1039/b414254c
Petroleum Research Fund
University of Southern California. Loker Hydrocarbon Research Institute
Article - Journal
© 2005 Royal Society of Chemistry, All rights reserved.