Title

Chromosome Dynamics: New Light on Aurora B Kinase Function

Abstract

Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromosome condensation and cohesion.

Department(s)

Biological Sciences

Keywords and Phrases

Caenorhabditis elegans Proteins; Chromosomal Proteins, Non-Histone; Chromosome Segregation; Chromosomes; Dynein ATPase; Protein Kinases; Protein-Serine-Threonine Kinases; Animals; Autoantigens; Humans; Kinetochores; Microtubules; Mitosis; Saccharomyces cerevisiae Proteins; AURKA Protein, Human; AURKB Protein, Human; Aurkb Protein, Mouse; Aurora Kinase; Centromere Protein A; Centromere Protein E; Dynein Adenosine Triphosphatase; IPL1 Protein, S cerevisiae; Nonhistone Protein; Protein Kinase; Centromere; Genetics; Human; Metabolism; Mitosis; Note; Physiology

International Standard Serial Number (ISSN)

0960-9822; 1879-0445

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2002 Cell Press, All rights reserved.

PubMed ID

12121637

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