Title

Cell-Penetrating Peptides for Medical Theranostics and Targeted Drug Delivery

Abstract

We focus on three major topics in this chapter. First, we describe cellular uptake mechanisms of cell-penetrating peptides (CPPs). The pitfalls and complementary tools in conducting mechanistic studies of uptake are illustrated. Second, we depict applications of two powerful CPPs, activatable cell-penetrating peptides (ACPPs) and tumor internalizing RGD (iRGD) peptides, for medical imaging and drug delivery. A combinational approach with CPPs and the clustered regularly interspaced short palindromic repeats (CRISPR)- associated (Cas) protein 9 (CRISPR-Cas9) system may provide an alternative for gene delivery and editing. Lastly, we review the safety and biocompatibility of CPPs in medical applications.

Department(s)

Biological Sciences

Keywords and Phrases

Cell-Penetrating Peptide; Cellular Uptake Mechanisms; Targeted Drug Delivery and Genome Editing

International Standard Book Number (ISBN)

978-0-0810-0742-6; 978-0-0810-0736-5

Electronic OCLC #

1008764675

Print OCLC #

1043415906

Document Type

Book - Chapter

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2018 Elsevier, All rights reserved.

Share

 
COinS