Abstract

Three-dimensional (3D) bioprinting is an emerging technology in which scaffolding materials and cell-laden hydrogels may be deposited in a pre-determined fashion to create 3D porous constructs. A major challenge in 3D bioprinting is the slow degradation of melt deposited biopolymer. In this paper, we describe a new method for printing poly-caprolactone (PCL)/bioactive borate glass composite as a scaffolding material and Pluronic F127 hydrogel as a cell suspension medium. Bioactive borate glass was added to a mixture of PCL and organic solvent to make an extrudable paste using one syringe while hydrogel was extruded and deposited in between the PCL/borate glass filaments using a second syringe. The degradation of the PCL/borate glass composite scaffold with and without the presence of hydrogel was investigated by soaking the scaffold in minimum essential medium. The weight loss of the scaffold together with formation of a hydroxyapatite-like layer on the surface shows the excellent bioactivity of the scaffold.

Meeting Name

3rd CIRP Conference on BioManufacturing 2017 (2017: Jul. 11-14, Chicago, IL)

Department(s)

Biological Sciences

Second Department

Materials Science and Engineering

Third Department

Mechanical and Aerospace Engineering

Comments

Funding for this study was provided by Tulane University and the Pennington Biomedical Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords and Phrases

3D Bioprinting; Biopolymer/bioactive glass composite; Borate bioactive glass; Pluronic hydrogel

International Standard Serial Number (ISSN)

2212-8271

Document Type

Article - Conference proceedings

Document Version

Final Version

File Type

text

Language(s)

English

Rights

© 2017 Elsevier B.V., All rights reserved.

Creative Commons Licensing

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Share

 
COinS